TNA Pipelines

The MOSBRI pipelines are integrated access to a synergistic set of biophysical instruments and technologies. This will allow the TNA user to fully exploit the overarching expertise of the TNA site to tackle advanced questions.

As part of the MOSBRI project, Joint research activities (JRAs) will further develop and improve pipelines, including joint pipelines involving several TNA sites, and these will be made available for TNA users. Therefore, the pipeline list below is expected to change over the lifetime of MOSBRI.

Current available pipelines, with varied instrumentation at each site, include:

  • Membrane proteins in membrane models, in vitro and/or in-cellulo (3, 4, 5, 6, 8)
  • Time-resolved folding/unfolding/binding studies (including analysis of intrinsically disordered proteins) (2, 3, 6, 7, 12)
  • Amyloid proteins and fibrillation studies: kinetics, shape, stability, formation (3, 4, 5, 7)
  • Dynamics and affinities in biomolecular self-assembly (all sites)
  • Protein binding to prosthetic groups and paramagnetic centres (10, 12)
  • Protein sample profiling and optimisation for monodispersity/stability (1, 2, 6, 7, 9, 11, 13)
  • Small-molecule and solvent screening (1, 13)

The numbers after each entry in the pipeline list refer to the TNA sites, see the table below.

When applying for TNA via pipelines:

  • You can apply directly using the option Access to MOSBRI pipelines. A TNA site is chosen as part of the application process: please refer to the full TNA site/partner descriptions linked below for details of the services offered.
  • Should a choice of site be unclear, then MOSBRI offers expert counselling, apply using the option Project Maturation.

TNA sites marked with an asterisk (*) offer remote access in the form of sample ship-in services. See the TNA site description for details about this offer.

TNA sites marked with a double asterisk (**) offer remote access in the form of products. See the Products page for a description of the offer.

1)Pasteur-PFBMIMolecular Biophysics core facility,
Institut Pasteur, FR **
View full partner description
2)AU-SRCDSRCD Facility at ASTRID2,
Aarhus University, DK
View full partner description
3)ULBCentre for Structural Biology and Bioinformatics,
Université Libre de Bruxelles, BE *
View full partner description
4)LAMBSLaboratory for Advanced Microscopy Bioimaging Spectroscopy,
Universita Degli Studi Di Genova, IT *
View full partner description
5)RUG-BPZernike Institute for Advanced Materials,
Rijksuniversiteit Groningen, NL
View full partner description
6)EMBL-SPCSample Preparation and Characterisation Facility,
EMBL Hamburg (HH), DE *
View full partner description
7)ProLinCPROtein folding and Ligand INteraction Core facility,
Linköpings Universitet, SE *
View full partner description
8)NICMolecular Interactions, Department of Molecular Biology and Nanobiotechnology,
National Institute of Chemistry, SI *
View full partner description
9)ISMB-BIOPHYSXProtein Crystallography and Biophysics Centre,
Birkbeck College, University of London, UK *
View full partner description
10)EPR-MRSEPR-Facility Bioénergétique et Ingénierie des Protéines,
CNRS & Aix-Marseille University, FR *
View full partner description
11)MoB-IBTCentre of Molecular Structure,
Institute of Biotechnology of the Czech Academy of Sciences, CZ *
View full partner description
12)DSB-UROMSapienza University of Rome, IT *
View full partner description
13)BIFI-LACRIMAInstitute for Biocomputation and Physics of Complex Systems,
University of Zaragoza, ES *
View full partner description